Modeling the Budding Yeast Cell Cycle

net1∆ cdc20-ts

debug: ,
test user =
test db =

Simulation:

Change of parameters: kasrent=1, kasrentp=0.005, ks20'=ks20"=0.
Arrest: Mitotic exit at t=196 min with sister chromatids still attached.

Experiments:

Visintin, R., Hwang, E.S., Amon, A. (1999). Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398:818-823.
[Abstract] [Article]
Experimental results: Table 1, inviable.
Comments: Sister chromatids do not separate (Pds1 is high at exit of mitosis).